Stock Update (NASDAQ:EXAS): EXACT Sciences Corporation and MD Anderson Cancer Center Announce Partnership to Develop Screening and Diagnostic Tests for Lung Cancer

EXACT Sciences Corporation (NASDAQ:EXAS) and The University of Texas MD Anderson Cancer Center announced an agreement to jointly develop and commercialize blood-based screening and diagnostic tests for the early detection of lung cancer.

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This unique collaboration seeks to build upon MD Anderson’s extensive research into predictive biomarkers for lung cancer and Exact Sciences’ successful development and commercialization of Cologuard®, the only FDA-approved, non-invasive stool-based DNA colon cancer screening test. The two groups plan to develop a groundbreaking new blood test that targets biomarkers associated with lung cancer.

The collaboration specifically aims at developing a blood-based lung cancer screening test to determine the need for low-dose computed tomography (LDCT). This test would offer the opportunity to screen nearly 11 million Americans considered high-risk smokers and former smokers. The partnership is also aimed at developing a diagnostic test to determine the malignant status of nodules found through LDCT screening. This test would be valuable to nearly four million Americans diagnosed with lung nodules each year.

“Our common vision is to help win the war on cancer through early detection. Taking on lung cancer offers an opportunity to build on the success of Cologuard,” said Exact Sciences’ Chairman and CEO Kevin Conroy. “A simple blood test to complement a LDCT scan could significantly improve early-stage lung cancer detection. Our experience working with regulators and insurers coupled with MD Anderson’s world-class research and development capabilities are an ideal match to make a meaningful difference in the war on cancer.”

The American Cancer Society estimates that lung cancer will be diagnosed in 221,200 Americans and cause 158,040 deaths in the United States this year. Currently, more than half of lung cancer cases are diagnosed at an advanced stage, after symptoms appear, when the five-year survival rate is in the low single digits. If detected at an early stage, lung cancer’s five-year survival rate can be as high as 80 percent.

“Lung cancer is, and will continue to be, America’s leading cancer killer unless we identify new approaches to diagnose it early, at its most treatable stages,” said Sam Hanash, M.D., Ph.D., director of MD Anderson’s Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer. “Our collaboration with Exact Sciences provides a great opportunity to create tests that could shift the lung cancer detection paradigm for the benefit of patients.”

Hanash’s research spans a variety of biomarker types – including DNA, proteins, metabolites and autoantibodies. “Our goal is to choose the best-performing biomarkers for our panel across multiple technologies,” Hanash said, as opposed to the more common practice of relying on a single type of biomarker.

The initiative is part of MD Anderson’s Moon Shots Program, a goal-oriented, multidisciplinary effort harnessing available knowledge and new disruptive technologies to dramatically reduce cancer mortality through prevention, early detection and curative treatments. The program’s innovative approach focuses initially on eight cancers: lung, breast, ovarian, prostate, melanoma, chronic lymphocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Early detection was chosen as a flagship project of the Lung Cancer Moon Shot, funded initially by the Lyda Hill Foundation.

Currently LDCT scanning is reimbursed by Medicare for high-risk smokers and received a Grade B rating from the U.S. Preventive Services Task Force, leading clinicians nationwide to increase screening programs in recent years. The clinical challenge is that while LDCT is about 94 percent sensitive, it has a 73 percent specificity for the initial screen. As a consequence of the lower specificity of LDCT, 96 percent of all nodules discovered via LDCT scans are benign, leading to unnecessary and often harmful invasive procedures, radiation exposure and high costs. More information about improving lung cancer detection with a new cost-effective blood-based test is available in this report from Exact Sciences and MD Anderson(Original Source)

Shares of Exact Sciences closed yesterday at $27.45 . EXAS has a 1-year high of $29.97 and a 1-year low of $13.86. The stock’s 50-day moving average is $23.96 and its 200-day moving average is $24.98.

On the ratings front, Exact Sciences has been the subject of a number of recent research reports. In a report issued on May 21, Jefferies Co. analyst Brandon Couillard reiterated a Buy rating on EXAS, with a price target of $33, which implies an upside of 20.2% from current levels. Separately, on May 5, JMP’s J T Haresco reiterated a Hold rating on the stock and has a price target of $31.

According to, which ranks over 7,500 financial analysts and bloggers to gauge the performance of their past recommendations, Brandon Couillard and J T Haresco have a total average return of 18.8% and 9.0% respectively. Couillard has a success rate of 82.4% and is ranked #136 out of 3610 analysts, while Haresco has a success rate of 53.3% and is ranked #1413.

In total, 3 research analysts have assigned a Hold rating and 3 research analysts have given a Buy rating to the stock. When considering if perhaps the stock is under or overvalued, the average price target is $30.50 which is 11.1% above where the stock closed yesterday.

Exact Sciences Corp is a molecular diagnostics company currently focused on the early detection and prevention of colorectal cancer. It has developed a noninvasive, patient friendly screening test called Cologuard(R).

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