Oncolytics Biotech, Inc. (USA) (NASDAQ:ONCY) today announced that a series of poster presentations by the Company’s research collaborators will be made at the 2015 AACR Annual Meeting being held from April 18th to 22nd, 2015 in Philadelphia, PA.
“Our preclinical program remains focused on identifying additional drug combinations, indications and genetic populations that we can consider for future clinical testing,” said Dr. Brad Thompson, President and CEO of Oncolytics. “The findings presented at the AACR meeting are all supportive of additional work with these treatment combinations.”
The first abstract/poster titled “Combination therapy of reovirus and PD-1 blockade effectively established tumor control via innate and adaptive immune responses,” was authored by Melcher, et al. The authors concluded that in an immune-competent murine melanoma model the combination therapy of reovirus with PD-1 blockade confers significant survival benefit, by augmenting tumor-specific natural killer (NK) responses and specifically attenuating tumor-specific immunosuppression. These data also suggest that combination of PD-1 inhibition therapy with reovirus oncolytic/immunotherapy represents a readily translatable method to enhance the therapeutic efficacy.
The second abstract/poster titled “Oncolytic virus (RT3D) administration in combination with cetuximab in head and neck squamous cell cancer (HNSCC) models harboring active EGFR/RAS/P13K signaling,” was authored by Psyrri, et al. The authors concluded that in a transgenic mouse to test the therapeutic effect of combination of cetuximab treatment and RT3D infection in a mouse model of ras-driven oral SCC, RT3D infection exhibits a strong oncolytic effect in cetuximab resistant HNSCC with activated EGFR/RAS/MAPK signaling. The findings provided evidence that RAS independent molecular mechanisms can also support the RT3D proliferation in this subset of HNSCC.
The third abstract/poster titled “Synergistic mechanisms of oncolytic reovirus with bortezomib in overcoming therapy resistance of multiple myeloma,” was authored by Morris et al. Using a number of multiple myeloma cell lines the authors concluded that not all multiple myeloma cell lines are amenable to reovrius mediated cell death and that this has important implications for the future use of reovirus as a therapeutic agent. Understanding the signaling pathways of resistant tumours will help develop a more personalized approach for reovrius therapy for multiple myeloma patients in the future.
The fourth abstract/poster titled “Oncolytic viral therapy with immune modulation is an effective novel treatment strategy for non-small cell lung cancer (NSCLC),” was also authored by Morris et al. Using reovirus and sunitinib the researchers tested series of human and mouse lung cancer cell lines and concluded that reovirus and sunitinib combination therapy holds promise as a novel treatment strategy for NSCLC.
Copies of the abstracts and posters, when available, will be found on the Oncolytics website at:http://www.oncolyticsbiotech.com/for-investors/presentations. (Original Source)
Shares of Oncolytics closed last Friday at $0.761 . ONCY has a 1-year high of $1.69 and a 1-year low of $0.40. The stock’s 50-day moving average is $0.80 and its 200-day moving average is $0.63.
On the ratings front, Oncolytics has been the subject of a number of recent research reports. In a report issued on March 18, Needham analyst Chad Messer reiterated a Buy rating on ONCY, with a price target of $1.50, which represents a potential upside of 97.1% from where the stock is currently trading. Separately, on March 17, Canaccord Genuity’s Neil Maruoka reiterated a Buy rating on the stock .
According to TipRanks.com, which ranks over 7,500 financial analysts and bloggers to gauge the performance of their past recommendations, Chad Messer and Neil Maruoka have a total average return of -1.2% and 15.8% respectively. Messer has a success rate of 33.3% and is ranked #2954 out of 3573 analysts, while Maruoka has a success rate of 90.0% and is ranked #690.
Oncolytics Biotech Inc is a development stage biopharmaceutical company. It is engaged in the discovery and development of pharmaceutical products for the treatment of cancer.